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Related Experiment Videos

Experience with homograft mitral valve replacement

A S Kumar1, D A Kumar, H Chander

  • 1Department of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India.

The Journal of Heart Valve Disease
|May 20, 1998
PubMed
Summary

Homograft mitral valve replacement (HMVR) shows promising early results for patients with severe mitral stenosis and regurgitation. This study reports good function and acceptable mortality rates for HMVR in a small patient cohort.

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Area of Science:

  • Cardiovascular Surgery
  • Cardiac Valve Repair & Replacement
  • Thoracic Surgery

Background:

  • Homograft mitral valve replacement (HMVR) is explored as a potentially superior alternative to prosthetic valve replacement.
  • Rheumatic heart disease was the primary etiology in all patients undergoing HMVR.

Purpose of the Study:

  • To report the early clinical experience with homograft mitral valve replacement (HMVR).
  • To evaluate the safety and efficacy of HMVR in patients with severe mitral valve disease.

Main Methods:

  • Twenty-four patients underwent HMVR between May 1994 and May 1995.
  • Patients had severe calcific mitral stenosis (MS) or mixed MS and mitral regurgitation (MR).
  • Follow-up included clinical assessment, echocardiography, and magnetic resonance imaging.

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Main Results:

  • Early mortality was 12% (3/24) and late mortality was 8% (2/24).
  • Sixteen patients demonstrated satisfactory homograft valve function at a mean follow-up of 18 months.
  • Postoperative echocardiography revealed trivial to mild mitral regurgitation in most patients, with no residual mitral stenosis.

Conclusions:

  • Homograft mitral valve replacement (HMVR) can be performed with good early clinical outcomes.
  • HMVR appears to be a viable option for selected patients with severe mitral valve disease.