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Advances in cubicle design using computational fluid dynamics as a design tool

G Curry1, H C Hughes, D Loseby

  • 1Department of Laboratory Animal Science, SmithKline Beecham Pharmaceuticals, Welwyn, Hertfordshire, UK.

Laboratory Animals
|May 20, 1998
PubMed
Summary

Computational fluid dynamic (CFD) studies optimized animal cubicle ventilation. The best design featured low-level air supply and high-level exhaust, minimizing turbulence and ensuring containment for specialized animal models.

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Area of Science:

  • Laboratory animal science
  • Facility design and engineering
  • Biocontainment systems

Background:

  • Animal facility refurbishments require enhanced experimental space and containment.
  • Specialized animal models necessitate optimized housing conditions.
  • Effective ventilation is crucial for maintaining a safe and controlled research environment.

Purpose of the Study:

  • To design a cubicle containment system for increased experimental space.
  • To provide containment for specialized animal models.
  • To optimize ventilation strategies through computational fluid dynamic (CFD) analysis.

Main Methods:

  • Utilized computational fluid dynamic (CFD) studies to simulate airflow dynamics.
  • Evaluated various air supply and exhaust configurations.

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  • Assessed different animal load scenarios within the cubicles.
  • Optimized ventilation rates to achieve desired containment levels.

    • Main Results:

    • Identified an optimal ventilation configuration for cubicle containment.
    • The optimal setup involved two opposed, low-level supply ducts and high-level exhaust.
    • Achieved a ventilation rate of 20 air changes per hour.
    • Minimized air turbulence, stagnation, and entrainment within the cubicles.

    Conclusions:

    • The optimized cubicle containment system effectively balances increased experimental space with necessary biocontainment.
    • The validated CFD approach provides a reliable method for designing efficient animal housing ventilation.
    • The specific airflow configuration ensures a safe and stable environment for specialized animal models.