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Related Experiment Videos

[Hypertonic-hyperoncotic volume replacement with Tensitone]

L Vokrouhlický1, R Soucek

  • 1Oddĕlení klinické farmakologie VUFB, a.s., Praha.

Casopis Lekaru Ceskych
|May 20, 1998
PubMed
Summary

Tensitone, a hypertonic-hyperoncotic solution, effectively restores volume in patients with massive blood loss. This rapid, small-volume resuscitation rapidly improves hemodynamics and diuresis with good safety.

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Area of Science:

  • Emergency Medicine
  • Critical Care Medicine
  • Pharmacology

Background:

  • Hypertonic-hyperoncotic solutions (HHS) represent an advanced approach to volume restoration in hypovolemia.
  • Tensitone (7.5% NaCl in 6% dextran 70) is a specific HHS formulation evaluated for clinical use.

Purpose of the Study:

  • To assess the efficacy and safety of Tensitone for volume restoration in patients experiencing massive acute blood loss.
  • To compare the effects of Tensitone with standard volume expanders in managing hemorrhage.

Main Methods:

  • A multicenter clinical study involving 81 patients with massive traumatic or peroperative hemorrhage.
  • Rapid infusion of a small volume of Tensitone (4 ml/kg) was administered and compared to standard volume expanders (N=34).
  • Evaluation focused on hemodynamic parameters, diuresis, and overall patient condition.

Main Results:

  • Tensitone demonstrated a significantly faster and more pronounced normalization of blood pressure (p < 0.01) and heart rate (p < 0.05) compared to standard expanders.
  • Rapid hemodynamic improvement was observed within 10 minutes, with sustained effects for at least 2 hours.
  • Central venous pressure and diuresis also showed significant improvement (p < 0.01) with Tensitone.
  • The preparation exhibited good tolerance, with serious adverse effects like thrombophlebitis occurring in only 3.6% of patients.

Conclusions:

  • Tensitone is an effective and safe option for rapid, small-volume resuscitation in cases of massive blood loss.
  • Its application aligns with contemporary practices in intensive care and acute medicine.
  • The study supports the use of Tensitone for prompt hemodynamic stabilization during critical bleeding events.

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