Related Experiment Video
Updated: Aug 7, 2026

Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
Immunopathology of T-lymphocyte subsets in juvenile and rapidly progressive periodontitis
M Y Abdel-Razzak1, N E Abo-Azma, E el-Zefzaf
1Faculty of Dentistry, Tanta University.
Abstract:
The immunopathology of T4 & T8 cell subsets in gingival tissues from 20 patients affected with either juvenile (JP) or rapidly progressive periodontitis (RPP) were studied using immunoperoxidase method for monoclonal antibodies of T4 & T8. Results were compared with gingival samples taken from systemically and periodontally healthy subjects. T4 subsets were found to be significantly elevated in JP & RPP, when compared with controls. Yet it was found to be higher in JP than in RPP, while T8 subsets were found to be depressed in both types of diseases. Those findings could contribute to the immunopathogenesis of JP & RPP.
Related Concept Videos
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Cells of the Adaptive Immune Response
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

