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Effect of addition antimicrobial agents to denture reliners
H el-Charkawi1, E A el-Said, H M Safouh
1Prosthodontics Dep., Faculty of Oral and Dental Medicine, Cairo University.
Egyptian Dental Journal
|July 1, 1994
Summary
Nystatin effectively inhibits Candida albicans in denture liners for over 32 weeks without compromising mechanical properties. Polynoxylin requires high concentrations that negatively impact liner strength.
Area of Science:
- Biomaterials Science
- Dental Materials
- Antimicrobial Agents
Background:
- Denture stomatitis, often caused by Candida albicans, necessitates antimicrobial agents in denture liners.
- Evaluating the efficacy and material compatibility of incorporated antimicrobials is crucial for effective denture care.
Purpose of the Study:
- To assess the antimicrobial activity and duration of nystatin and polynoxylin incorporated into denture liners.
- To determine the impact of these drugs on the mechanical properties and chemical composition of the liner material.
Main Methods:
- Nystatin and polynoxylin were incorporated into denture liners at various concentrations.
- Antimicrobial activity against Candida albicans and bacterial strains was tested.
- Mechanical properties and chemical composition of the liners were analyzed post-incorporation.
Main Results:
- Nystatin (3-10% by weight) demonstrated effective inhibition of Candida albicans, with a direct correlation between concentration and duration of action.
- A 10% nystatin concentration maintained inhibitory effects for at least 32 weeks without altering liner strength.
- Polynoxylin required high concentrations (40-60%) for antimicrobial activity, which adversely affected the mechanical properties of the denture liner.
Conclusions:
- Nystatin is a suitable antimicrobial agent for denture liners, offering prolonged efficacy without compromising material integrity.
- Polynoxylin's adverse effects on mechanical properties at effective concentrations limit its use in denture liners.