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Obsessional symptoms associated with risperidone treatment

R Mahendran1

  • 1Woodbridge Hospital and Institute of Mental Health, Buangkok Green, Singapore.

The Australian and New Zealand Journal of Psychiatry
|May 20, 1998
PubMed
Summary
This summary is machine-generated.

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Risperidone treatment in a patient with schizophrenia precipitated new-onset obsessional symptoms. These symptoms improved with clomipramine, highlighting a potential adverse effect of antipsychotic medications.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Schizophrenia is a chronic mental illness often treated with antipsychotic medications.
  • Risperidone is a widely used second-generation antipsychotic.
  • Obsessive-compulsive symptoms are not typically associated with risperidone treatment.

Observation:

  • A 26-year-old female with chronic schizophrenia developed new-onset obsessional symptoms after two weeks of risperidone treatment.
  • The patient had no prior history of obsessive-compulsive disorder.
  • Risperidone was initiated due to side effects from other antipsychotic medications.

Findings:

  • Obsessional symptoms emerged during risperidone therapy.
  • The obsessional symptoms responded effectively to a low dose of clomipramine.

Related Experiment Videos

  • This suggests a potential link between risperidone and the precipitation of obsessive-compulsive symptoms.
  • Implications:

    • Clinicians should be aware of the potential for atypical antipsychotics like risperidone to induce or worsen obsessive-compulsive symptoms.
    • Careful monitoring for emergent psychiatric symptoms is crucial during antipsychotic treatment.
    • Further research is warranted to understand the mechanism underlying this adverse effect.