Platelet activation during dobutamine stress echocardiography
M T Galloway1, T G Paglieroni, T Wun
1Division of Cardiology, University of California Davis School of Medicine, Sacramento, USA.
American Heart Journal
|May 20, 1998
Summary
Dobutamine stress echocardiography (DSE) activates platelets in vivo, potentially increasing myocardial infarction risk. This platelet activation may stem from dobutamine’s synergistic effect with natural agonists.
Area of Science:
- Cardiology
- Hematology
- Pharmacology
Background:
- Dobutamine stress echocardiography (DSE) is a key diagnostic tool for coronary artery disease.
- While generally safe, DSE has been associated with rare cases of myocardial infarction, exceeding rates seen with exercise treadmill testing (ETT).
Purpose of the Study:
- To investigate the direct effects of dobutamine on platelet activation.
- To compare in vitro and in vivo platelet responses during DSE versus ETT.
Main Methods:
- Platelet activation was assessed using flow cytometry to measure CD62 expression.
- In vitro studies exposed platelets to dobutamine and epinephrine.
- In vivo studies analyzed platelet activation in patients undergoing DSE and ETT.
Main Results:
- Dobutamine synergistically enhanced epinephrine-induced CD62 expression in vitro.
- In vivo, DSE induced a dose- and time-dependent increase in platelet CD62 expression (p = 0.02).
- Platelet activation was not observed in patients undergoing ETT.
Conclusions:
- Platelet activation occurs in patients during dobutamine stress echocardiography.
- This activation may be attributed to dobutamine’s synergistic interaction with physiological platelet agonists.
- Findings suggest a potential mechanism linking DSE to adverse cardiac events.
More Related Videos
Related Concept Videos
01:20Imaging Studies for Cardiovascular System II:Types of Echocardiography
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
01:30Dysrhythmias V: Evaluating Dysrhythmias
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...