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Surgery for metastatic melanoma

S M Sharpless1, T K Das Gupta

  • 1Department of Surgical Oncology, University of Illinois at Chicago, 60612-7322, USA. sonyams@uic.edu

Seminars in Surgical Oncology
|May 20, 1998
PubMed
Summary

Surgical resection of metastatic melanoma can significantly improve survival for select patients. Complete removal of isolated metastases offers the best prognosis, potentially extending survival by years.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Dermatology

Background:

  • Malignant melanoma with distant metastases typically has a poor prognosis, with median survival of 5-8 months.
  • Surgical intervention can offer palliative benefits and prolong life in select metastatic melanoma patients.

Purpose of the Study:

  • To evaluate the prognostic impact of surgical resection in patients with metastatic melanoma.
  • To identify factors influencing survival outcomes following surgical intervention for metastatic melanoma.

Main Methods:

  • Review of outcomes for patients with metastatic melanoma undergoing surgical resection of metastases.
  • Analysis of prognostic factors including metastasis location, completeness of resection, and disease-free interval.

Main Results:

  • Complete resection of isolated, non-visceral metastases with clear margins and a longer disease-free interval significantly improves prognosis, with median survival approaching 10 years and 5-year survival up to 35%.
  • Surgical resection of lung metastases can lead to a median survival of 19 months and 25% 5-year survival.
  • Resection of brain or gastrointestinal metastases extends median survival to approximately 10 months, improving quality of life.

Conclusions:

  • Surgical resection is a valuable treatment modality for selected patients with metastatic melanoma, particularly for isolated non-visceral or lung metastases.
  • Individual patient assessment and adherence to general guidelines are crucial for optimizing surgical intervention in metastatic melanoma.
  • The role of surgery in metastatic melanoma management remains critical, with potential for significant survival benefits in carefully selected cases.

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