Peripheral primitive neuroectodermal tumor presenting with diffuse cutaneous involvement and 7;22 translocation
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Updated: Oct 29, 2026
Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
Published on: August 25, 2023
L M Smith1, R H Adams, A R Brothman
1Department of Radiation Oncology, University of Utah Health Sciences Center, Salt Lake City 84132, USA.
Abstract:
We report an unusual case of peripheral primitive neuroectodermal tumor (pPNET) in an infant presenting with congenital cutaneous nodules and a t(7;22)(p21;q11.2). The biologic behavior of the tumor diverged over time from a slowly growing tumor with multiple cutaneous nodules to a more aggressive neoplasm characterized by pulmonary metastases and a soft tissue mass showing additional cytogenetic alterations.
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