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Systemic retinoids. What's new?
1Department of Dermatology, University Hospital, Geneva, Switzerland.
Dermatologic Clinics
|May 20, 1998
Summary
Oral retinoids like isotretinoin and acitretin are available, but no new systemic compounds have emerged. This review covers current uses, side effects, and future drug development based on basic research in retinoid pharmacology.
Area of Science:
- Dermatology and Pharmacology
- Molecular Biology
Background:
- Retinoids are crucial in dermatology and molecular biology.
- Despite advances, no novel systemic retinoid compounds have been approved for clinical use.
Purpose of the Study:
- To review current indications for existing oral retinoids.
- To discuss recently reported adverse effects of systemic retinoids.
- To explore emerging research concepts for future retinoid drug development.
Main Methods:
- Literature review of existing oral retinoids (isotretinoin, acitretin, tretinoin).
- Analysis of recently reported undesirable effects.
- Discussion of basic research findings relevant to new drug discovery.
Main Results:
- Current systemic retinoids have established therapeutic roles.
- New undesirable effects associated with these drugs have been documented.
- Basic research provides a foundation for novel retinoid pharmacology.
Conclusions:
- Existing oral retinoids remain important therapeutic options.
- Ongoing research into retinoid mechanisms may yield next-generation systemic drugs.
- Further investigation into retinoid pharmacology is essential for advancing treatment options.