Systemic retinoids. What's new?

Despite major advances in the molecular biology and pharmacology of retinoids, no new compound has been developed for systemic use. This article addresses some questions related to the indications of oral retinoids already on the market, e.g. isotretinoin, acitretin, as well as tretinoin, reviews some recently reported undesirable effects, and discusses the recent concepts generated by basic research that may lead to new drugs to be used in pharmacology.