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Analysis of pharmaceutically-important thioxanthene derivatives
F Belal1, M M Hefnawy, F A Aly
1Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
Journal of Pharmaceutical and Biomedical Analysis
|May 20, 1998
Summary
This review summarizes analytical methods for thioxanthene derivatives used in pharmaceuticals. It covers analyses in drug products and biological samples, including metabolism and pharmacokinetics.
Area of Science:
- Pharmaceutical Chemistry
- Analytical Chemistry
- Pharmacology
Background:
- Thioxanthene derivatives are compounds of pharmaceutical interest.
- Analytical methods are crucial for their quality control and pharmacokinetic studies.
- A comprehensive review of existing analytical techniques is needed.
Purpose of the Study:
- To review and consolidate reported analytical methods for thioxanthene derivatives.
- To cover methods applicable to both pharmaceutical dosage forms and biological fluids.
- To briefly discuss the metabolism and pharmacokinetics of these compounds.
Main Methods:
- Literature review of 92 references.
- Compilation of analytical techniques.
- Discussion of pharmacokinetic and metabolic data.
Main Results:
- A wide range of analytical methods for thioxanthene derivatives has been reported.
- Methods suitable for analysis in dosage forms and biological matrices are identified.
- Key aspects of thioxanthene metabolism and pharmacokinetics are summarized.
Conclusions:
- The review provides a valuable resource for researchers and analysts working with thioxanthene derivatives.
- Understanding analytical methods is essential for drug development and therapeutic monitoring.
- Further research may benefit from this consolidated overview of analytical strategies.