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Luteinizing hormone and human chorionic gonadotropin decrease type 2 5 alpha-reductase and androgen receptor protein

J Bird1, X Li, Z M Lei

  • 1Department of Obstetrics and Gynecology, University of Louisville Health Sciences Center, Kentucky 40292, USA.

The Journal of Clinical Endocrinology and Metabolism
|May 20, 1998
PubMed
Summary
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Human skin responds to luteinizing hormone (LH) and human chorionic gonadotropin (hCG). Studies show LH/hCG can decrease levels of 5 alpha-reductase and androgen receptors in skin tissue.

Area of Science:

  • Endocrinology
  • Dermatology
  • Reproductive Biology

Background:

  • The skin expresses androgen receptors and enzymes like 5 alpha-reductase, which are crucial for androgen metabolism.
  • Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are key reproductive hormones that can affect various tissues.
  • The specific regulatory roles of LH and hCG on skin androgen pathways are not fully understood.

Purpose of the Study:

  • To investigate the potential regulatory effects of LH/hCG on type 2 5 alpha-reductase and androgen receptor protein levels in human skin.
  • To determine if LH/hCG can modulate the expression of key proteins involved in androgen metabolism within skin tissue.

Main Methods:

  • Human skin samples were obtained from women undergoing surgical procedures.

Related Experiment Videos

  • Skin explants were incubated with or without human chorionic gonadotropin (hCG).
  • Western blotting was employed to quantify protein levels of type 2 5 alpha-reductase and androgen receptors.

    • Main Results:

    • Treatment with hCG led to a significant, time- and dose-dependent reduction in both 5 alpha-reductase and androgen receptor levels.
    • The observed effects of hCG were replicated by LH but not by other glycoprotein hormones or their subunits.
    • These findings indicate that human skin is a responsive nongonadal tissue to LH and hCG.

    Conclusions:

    • LH and hCG can modulate key components of the androgen pathway in human skin.
    • The study provides evidence for the direct impact of LH/hCG on skin's metabolic and receptor functions.
    • Further research is needed to elucidate the clinical and biological significance of this hormonal regulation in the skin.