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Related Experiment Videos

Interactions between Epstein-Barr virus and the cell cycle control machinery

A J Sinclair1, M Fenton, S Delikat

  • 1School of Biological Sciences, University of Sussex, Brighton, UK.

Histology and Histopathology
|May 20, 1998
PubMed
Summary

Epstein-Barr virus (EBV) infects most people, often asymptomatically. This review details EBV

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Area of Science:

  • Virology
  • Oncology
  • Cell Biology

Background:

  • Epstein-Barr virus (EBV) establishes lifelong persistence in the majority of the human population.
  • While often asymptomatic, EBV is linked to various diseases, including infectious mononucleosis, lymphomas, and carcinomas.

Purpose of the Study:

  • To review the evidence connecting EBV to associated human diseases.
  • To highlight recent advancements in understanding EBV's interaction with cell cycle control.

Main Methods:

  • Comprehensive literature review of studies investigating EBV.
  • Analysis of research on EBV's role in pathogenesis.
  • Examination of molecular mechanisms underlying EBV-host interactions.

Main Results:

  • Compilation of evidence linking EBV to infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's disease, gastric carcinomas, and other lymphoproliferative disorders.
  • Identification of key interactions between EBV and cellular cycle regulators.

Conclusions:

  • EBV is a significant factor in the etiology of numerous human cancers and lymphoproliferative diseases.
  • Understanding EBV's manipulation of the cell cycle is crucial for developing targeted therapies.

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