Substrate and inhibitor complexes of dihydrofolate reductase from amethopterin-resistant L1210 cells

Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates.

Advances in enzyme regulation·1997

Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate.

Cancer research·1995

Novel substrate analogs delineate an endocytotic mechanism for uptake of folate via the high-affinity, glycosylphosphatidylinositol-linked transport protein in L1210 mouse leukemia cells.

Oncology research·1995

Tumor targeting: activation of prodrugs by enzyme-monoclonal antibody conjugates.

Trends in biotechnology·1994

The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

Advances in enzyme regulation·1994

Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate.

Biochemistry·1992

Activation of Cu(II)-reducing ability of monoamine neurotransmitters triggered by amyloid-β fibrillization.

Archives of biochemistry and biophysics·2026

The mucosal redox gateway for dietary iron absorption: integrating gastrointestinal mucus, Fe(II)/Fe(III) speciation and ligand-centred valence tautomerism.

Archives of biochemistry and biophysics·2026

Nitro-arachidonic acid inhibits prostaglandin endoperoxide H synthase 2 through histidine-mediated heme-binding conformational perturbation.

Archives of biochemistry and biophysics·2026

Mechanistic insights into nicotine oxidation by FAD-dependent nicotine dehydrogenase from Pseudomonas sp. HZN6.

Archives of biochemistry and biophysics·2026

Elucidation of d-alanine biosynthetic pathways in the hyperthermophiles: Characterization of alanine racemase from Thermus thermophilus and the structure and dual physiological functions of lysine racemase from Thermotoga maritima.

Archives of biochemistry and biophysics·2026

A matter of balance: Heme oxygenase-1 at the crossroads of healthy and pathological aging.

Archives of biochemistry and biophysics·2026

Endometrial Preparation for Frozen Embryo Transfer: Protocols and Pregnancy Outcomes.

JBRA assisted reproduction·2026

Effect of different sibling human embryo culture volumes on clinical outcomes: a retrospective cohort study.

JBRA assisted reproduction·2026

Embryo Morphology and Euploidy Rate: A Cross-Sectional Analysis of Day-3 and Blastocyst-Stage Quality.

JBRA assisted reproduction·2026

Clinical Profiles and Maternal-Neonatal Outcomes in Pregnancies Complicated by Hypertensive Disorders in Puerto Rico and gave Birth at the University District Hospital between 2020-2023.

Puerto Rico health sciences journal·2026

Association between serum vitamin D status and early pregnancy outcomes in first in vitro fertilization cycles with high-quality embryo transfer.

Clinical and experimental reproductive medicine·2026

A Rare Case of Preeclampsia-Associated Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in Twin Pregnancy Treated With Tolvaptan.

Cureus·2026

Related Experiment Videos

Substrate and inhibitor complexes of dihydrofolate reductase from amethopterin-resistant L1210 cells

Related Concept Videos

Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates.

Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate.

Novel substrate analogs delineate an endocytotic mechanism for uptake of folate via the high-affinity, glycosylphosphatidylinositol-linked transport protein in L1210 mouse leukemia cells.

Tumor targeting: activation of prodrugs by enzyme-monoclonal antibody conjugates.

The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate.

Activation of Cu(II)-reducing ability of monoamine neurotransmitters triggered by amyloid-β fibrillization.

The mucosal redox gateway for dietary iron absorption: integrating gastrointestinal mucus, Fe(II)/Fe(III) speciation and ligand-centred valence tautomerism.

Nitro-arachidonic acid inhibits prostaglandin endoperoxide H synthase 2 through histidine-mediated heme-binding conformational perturbation.

Mechanistic insights into nicotine oxidation by FAD-dependent nicotine dehydrogenase from Pseudomonas sp. HZN6.

Elucidation of d-alanine biosynthetic pathways in the hyperthermophiles: Characterization of alanine racemase from Thermus thermophilus and the structure and dual physiological functions of lysine racemase from Thermotoga maritima.

A matter of balance: Heme oxygenase-1 at the crossroads of healthy and pathological aging.

Endometrial Preparation for Frozen Embryo Transfer: Protocols and Pregnancy Outcomes.

Effect of different sibling human embryo culture volumes on clinical outcomes: a retrospective cohort study.

Embryo Morphology and Euploidy Rate: A Cross-Sectional Analysis of Day-3 and Blastocyst-Stage Quality.

Clinical Profiles and Maternal-Neonatal Outcomes in Pregnancies Complicated by Hypertensive Disorders in Puerto Rico and gave Birth at the University District Hospital between 2020-2023.

Association between serum vitamin D status and early pregnancy outcomes in first in vitro fertilization cycles with high-quality embryo transfer.

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Related Experiment Videos

Substrate and inhibitor complexes of dihydrofolate reductase from amethopterin-resistant L1210 cells

Related Concept Videos

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