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Related Experiment Videos

Increased circulating thrombomodulin in children with septic shock

B Krafte-Jacobs1, R Brilli

  • 1Division of Critical Care Medicine, Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Critical Care Medicine
|May 20, 1998
PubMed
Summary

Children with septic shock show higher plasma thrombomodulin levels, indicating endothelial injury. These levels correlate with organ failure severity and mortality risk in pediatric septic shock patients.

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Area of Science:

  • Pediatric critical care medicine
  • Vascular biology
  • Sepsis research

Background:

  • Septic shock involves microcirculatory dysfunction and endothelial injury.
  • Plasma thrombomodulin is a marker of endothelial activation and damage.

Purpose of the Study:

  • To investigate elevated plasma thrombomodulin in pediatric septic shock.
  • To correlate thrombomodulin levels with organ failure and mortality.

Main Methods:

  • Prospective cohort study in a pediatric intensive care unit.
  • Enrolled 22 children with septic shock and 10 healthy controls.
  • Measured plasma thrombomodulin via ELISA every 6 hours for 72 hours in septic shock patients.

Main Results:

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  • Septic shock nonsurvivors had significantly higher thrombomodulin (10.6 ng/mL) than survivors (5.5 ng/mL) and controls (3.4 ng/mL).
  • Thrombomodulin concentrations increased with the number of organ system failures.
  • Both survivor and nonsurvivor septic shock patients had elevated thrombomodulin compared to controls.

    • Conclusions:

    • Elevated plasma thrombomodulin in pediatric septic shock suggests endothelial injury.
    • Thrombomodulin levels correlate with the extent of multiple organ system failure.
    • Plasma thrombomodulin may serve as a biomarker for endothelial damage severity and organ dysfunction in pediatric septic shock.