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Hyperlipoproteinemia (acc. to Fredrickson's classification) in patients with myocardial infarction and imminent
Insights
This study found that over 30% of ischemic heart disease patients exhibit abnormal blood lipid patterns. Type II A hyperlipoproteinemia was the most common disturbance observed in these patients.
Area of Science:
- Cardiology
- Clinical Biochemistry
Background:
- Ischemic heart disease (IHD) is a significant cause of mortality worldwide.
- Blood lipid abnormalities are established risk factors for cardiovascular diseases.
Purpose of the Study:
- To investigate the prevalence and types of blood lipid disturbances in patients with ischemic heart disease.
- To classify lipid patterns according to the Fredrickson classification in IHD patients.
Main Methods:
- Blood lipid levels were analyzed in 500 patients diagnosed with ischemic heart disease.
- Patients included those with myocardial infarction and imminent infarction.
- Lipid patterns were classified using the Fredrickson criteria.
Main Results:
- Blood lipid disturbances were identified in 152 patients (30.4%) of the total cohort.
- Among patients with lipid disturbances, Fredrickson type II A was most prevalent (67.8%), followed by type II B (16.4%) and type IV (15.8%).
- Across the entire cohort, type II A represented 20.6%, type II B 5%, and type IV 4.8% of cases.
Conclusions:
- A significant proportion of ischemic heart disease patients present with dyslipidemia.
- Fredrickson type II A hyperlipoproteinemia is a common lipid abnormality associated with ischemic heart disease.
Abstract:
In 500 cases (379 men and 121 women) of ischemic heart disease, including 428 patients with myocardial infarction and 72 -- with imminent infarction, blood lipid levels were determined. Blood samples were taken on fasting, by the end of hospitalization, from patients with myocardial infarction on the 18th-21st day of disease, and from those with imminent infarction after cessation of pain. In 152 patients (30.4%), including 87 with infarction and 65 with imminent infarction, disturbances in the blood lipid pattern were found and classified according to Fredrickson. When expressed as percentage against the material of 152 patients with blood lipid disturbances, type II A was found in 103 cases (67.8%), type II B -- in 25 cases (16.4%), and type IV -- in 24 cases (15.8%). When calculated against the whole material of 500 patients, type II A accounted for 20.6%, type II B -- for 5%, and type IV -- 4.8% of cases.