A computer model of the neural control of the lower urinary tract

Better understanding of the underlying working mechanism of the neural control of the lower urinary tract will facilitate the treatment of dysfunction with a neurogenic cause. We developed a computer model to study the effect of a neural control system on lower urinary tract behavior. To model the mechanical properties and neural control, assumptions had to be made. These assumptions were based, as much as possible, on knowledge and hypotheses taken from the literature. With valid assumptions, it should be possible to simulate normal as well as pathological behavior. To test the computer model, first, normal behavior of the lower urinary tract was simulated, and secondly, the known features of bladder outlet obstruction were simulated after the properties of the urethra were changed. The simulation results are comparable with measured data, so the assumptions on which the model is based could be valid. If the assumptions are valid, the feedback loops used in the model are also important feedback loops in vivo, and the model can be used to gain insight into the underlying mechanism of neural control.