[The relationship between p53 and PCNA in germ cell carcinoma]

To analyse the relationship between cellular proliferating status, p53 expressions and tumor biological characteristics, immunohistochemistry was used in 13 cases of testicular germ cell carcinoma paraffin section. The results show that PCNA-LI is higher significantly in invasive tumor group than in noninvasive group (P < 0.05). Although there were no significant differences of PCNA-LI, p53 between seminoma and nonseminoma, two parameters in the latter group were somewhat higher. There was a correlation of PCNA-LI with p53 in nonseminoma group (r = 0.64). It is concluded that PCNA-LI and p53 are both correlated positively with tumor differentiation.