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Synovial sarcoma: oncological and functional results
H J van der Heide1, R P Veth, M Pruszczynski
1Department of Orthopaedics, University Hospital, Nijmegen, The Netherlands.
Summary
Synovial sarcoma treatment outcomes were poor, with a high rate of pulmonary metastases and mortality. Functional results varied, with some patients experiencing complications like scarring and venous insufficiency.
Area of Science:
- Orthopedic Oncology
- Surgical Oncology
- Sarcoma Research
Background:
- Synovial sarcoma is a rare soft tissue sarcoma.
- Treatment efficacy and long-term outcomes require further investigation.
Purpose of the Study:
- To evaluate oncological and functional outcomes of synovial sarcoma treatment.
- Retrospective review of 20 patients treated at Nijmegen University Hospital.
Main Methods:
- Retrospective review of 20 synovial sarcoma patients.
- Analysis of tumor location, surgical stage (Enneking), and surgical margins.
- Assessment of oncological outcomes (metastasis, recurrence, survival) and functional results (MSTS score).
Main Results:
- Most common tumor location: lower extremity (12/20).
- High incidence of metastatic disease, with 8/12 patients developing metastases during follow-up.
- 14/20 patients died of metastatic disease; 4/20 had no evidence of disease at follow-up.
Conclusions:
- Synovial sarcoma treatment outcomes are generally poor, primarily due to pulmonary metastases.
- Functional outcomes varied, with some patients experiencing complications impacting their MSTS scores.