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Related Experiment Videos

Diastolic hibernation masquerading as constrictive pericarditis

B S Cain1, D R Meldrum, K S Joo

  • 1Department of Surgery, University of Colorado, Denver 80262, USA.

Journal of Cardiac Surgery
|July 1, 1997
PubMed
Summary

Diastolic hibernation, a reversible impairment of myocardial contractility, was observed in a patient with coronary artery disease. Surgical intervention corrected this condition, suggesting a new form of treatable restrictive cardiomyopathy.

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Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Cardiomyopathy Research

Background:

  • Hibernating myocardium traditionally linked to systolic dysfunction.
  • Constrictive pericarditis diagnosis in a 75-year-old patient with coronary artery disease.
  • Exploration of non-systolic dysfunction in myocardial hibernation.

Observation:

  • Patient presented with significant coronary artery disease.
  • Initial diagnosis of constrictive pericarditis.
  • Sternotomy revealed no pericarditis but significant diastolic dysfunction.

Findings:

  • Coronary revascularization led to immediate improvement in diastolic function.
  • Ex vivo analysis showed normal myocardial adrenergic responsiveness.
  • Demonstrated a reversible impairment of myocardial contractility.

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Implications:

  • Diastolic hibernation as a distinct clinical entity.
  • Potential for surgical correction of this condition.
  • Highlights a novel form of restrictive cardiomyopathy.