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Does the Pall TNA-1E parenteral nutrition admixture filter retain Malassezia furfur?
1School of Pharmacy, University of Otago, Dunedin, New Zealand.
Nutrition (Burbank, Los Angeles County, Calif.)
|May 20, 1998
Abstract:
Malassezia furfur has been shown to be capable of survival and reproduction in fat emulsions for parenteral nutrition, and this has been suggested as the source of serious systemic infections in neonatal intensive care units. Under conditions of use similar to those found in neonatal practice, the Pall TNA-1E filter was found to reliably retain this organism for up to 48 h.
Insights
Malassezia furfur can grow in parenteral nutrition fat emulsions, causing serious infections in neonatal intensive care units. A specific filter reliably retained this fungus for up to 48 hours in neonatal settings.
Area of Science:
- Microbiology
- Neonatal Care
- Medical Device Filtration
Background:
- Malassezia furfur is a fungus known to survive and reproduce in lipid emulsions used for parenteral nutrition.
- This organism is implicated as a source of systemic infections in neonatal intensive care units (NICUs).
Purpose of the Study:
- To evaluate the efficacy of the Pall TNA-1E filter in retaining Malassezia furfur from parenteral nutrition fat emulsions.
- To assess filter performance under conditions simulating neonatal clinical practice.
Main Methods:
- The Pall TNA-1E filter was tested for its ability to retain Malassezia furfur.
- Testing conditions mimicked those used in neonatal intensive care units.
Main Results:
- The Pall TNA-1E filter demonstrated reliable retention of Malassezia furfur.
- Effective retention was observed for a duration of up to 48 hours.
Conclusions:
- The Pall TNA-1E filter is effective in preventing Malassezia furfur contamination of parenteral nutrition in neonatal settings.
- This filtration method offers a potential strategy to reduce systemic fungal infections in neonates.