[Effects of continuous estradiol-progestogen treatment on hemostasis in postmenopausal women]

A study was undertaken to asses the effects of oral continuous hormone replacement therapy on haemostatic balance. Blood samples were drawn from 28 postmenopausal women (mean age 54.1 +/- 4.1) with severe climacteric complaints. All the women were treated for one year with a continuous oestradiol-progestogen regimen which was administrated daily and consisting of 2 mg 17 beta-oestradiol in combination with norethisteron acetate, 1 mg (Kliogest-Novo-Nordisk). Hormone replacement therapy had no effect on fibrinogen and thrombin time. Activated partial thromboplastin time as well as prothrombin time was significantly decreased (p < 0.05) respectively 1.7 +/- 3.1 s and 0.6 +/- 1.4 s. No women developed crural thrombosis during therapy.