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Magnetically aligned phospholipid bilayers with positive ordering: a new model membrane system

R S Prosser1, J S Hwang, R R Vold

  • 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093-0359, USA.

Biophysical Journal
|May 20, 1998
PubMed
Summary

Paramagnetic lanthanide ions induce stable, ordered smectic phospholipid phases in bicellar solutions. These novel membrane mimetics, particularly with thulium, offer potential for advanced structural studies.

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Area of Science:

  • Biophysics
  • Materials Science
  • Chemistry

Background:

  • Bicellar solutions of dimyristoylphosphatidylcholine (DMPC) and dihexanoylphosphatidylcholine (DHPC) form fluid phases.
  • Paramagnetic lanthanide ions can influence the organization of lipid bilayers.

Purpose of the Study:

  • To investigate the formation of stable, ordered phospholipid phases using paramagnetic lanthanide ions.
  • To explore the potential of these phases as membrane mimetics for structural analysis.

Main Methods:

  • Addition of trivalent paramagnetic lanthanide ions (Eu3+, Er3+, Tm3+, Yb3+) to DMPC/DHPC bicellar solutions.
  • Characterization of the resulting phases using techniques such as magnetic resonance and diffraction.

Main Results:

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  • Stable smectic phospholipid bilayer phases aligned with magnetic fields were generated.
  • Thulium-doped samples (Tm3+) exhibited a broad concentration (6-40 mM) and temperature (35-90 °C) range for this phase.
  • A transition from a fluid nematic discotic to an ordered smectic phase was observed, dependent on thulium concentration.

Conclusions:

  • Paramagnetic lanthanide ions, specifically those with positive magnetic susceptibility anisotropy, can induce stable, ordered smectic phospholipid phases.
  • These novel phases serve as effective membrane mimetics with significant potential for structural investigations using various spectroscopic and diffraction methods.