Related Experiment Video
Updated: Aug 10, 2026
09:18
A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
Intratympanic gentamicin treatment for Meniere's disease
W J McFeely1, G T Singleton, F J Rodriguez
1Department of Otolaryngology, University of Florida, Gainesville 32610-0264, USA.
Summary
This study shows intratympanic gentamicin is effective for Meniere
Area of Science:
- Otolaryngology
- Neurosurgery
- Neurology
Background:
- Meniere's disease is a debilitating inner ear disorder.
- Intractable cases require effective treatment options.
Purpose of the Study:
- To assess the safety and efficacy of a modified intratympanic gentamicin method.
- To evaluate treatment for unilateral or bilateral Meniere's disease.
Main Methods:
- Retrospective review of 25 patients treated between 1992-1996.
- Utilized two delivery systems, including novel flanged polyethylene tubing.
Main Results:
- 88% experienced vertigo spell absence; 12% achieved substantial control.
- 75% showed loss of caloric response; 20% had sensorineural hearing loss.
- New tubing system showed comparable results to older methods.
Conclusions:
- Intratympanic gentamicin is effective and relatively safe for intractable Meniere's disease.
- Polyethylene tubing offers potential advantages over T-tube delivery.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:15Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...