Related Experiment Video
Updated: Aug 7, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Management of clubfoot deformity in amyoplasia
H Niki1, L T Staheli, V S Mosca
1Children's Hospital and Medical Center, Seattle, Washington 98105, USA.
Insights
Posteromedial release effectively corrects clubfeet in amyoplasia patients. Longer nighttime splinting post-surgery reduces recurrence, while serial casting can correct deformities that do return.
Area of Science:
- Orthopedics
- Pediatric Orthopedics
- Congenital Limb Deformities
Background:
- Clubfoot is a common congenital deformity.
- Amyoplasia is a rare congenital disorder characterized by multiple joint contractures, including clubfoot.
- Effective management of clubfoot in amyoplasia is crucial for functional outcomes.
Purpose of the Study:
- To evaluate the long-term outcomes of surgical management for clubfeet in patients with amyoplasia.
- To identify factors associated with successful correction and recurrence of deformity.
Main Methods:
- Retrospective study of 41 clubfeet in 22 patients with amyoplasia.
- Treatment regimen included initial stretching casts, posteromedial release, and postoperative splinting.
- Mean follow-up duration of 118 months.
Main Results:
- 27% of clubfeet achieved correction without recurrence.
- 95% of feet were plantigrade and satisfactory at follow-up.
- Longer duration of nighttime splinting was associated with reduced recurrence (p < 0.05).
Conclusions:
- Posteromedial release is an effective surgical option for clubfeet in amyoplasia.
- Postoperative nighttime splinting is important for preventing recurrence.
- Serial casting can be effective for correcting recurrent deformities.
Abstract:
Forty-one clubfeet in 22 patients with amyoplasia were studied retrospectively at a mean duration after surgery of 118 months (range, 45-253). The clubfeet were managed by a regimen including initial stretching casts, posteromedial release, and postoperative splinting at night. The mean age at the time of surgery was 7.3 months. Correction of deformity without recurrence was achieved in 11 (27%). Recurrent deformity was corrected by serial casting in eight feet and required secondary operative procedures in 20 feet. In the feet without recurrence of deformity, the duration of splinting at night after surgery was significantly longer than in those with recurrence (p < 0.05). At follow-up, 39 (95%) feet were plantigrade and were considered satisfactory. Our findings suggest that most clubfeet in amyoplasia can be effectively corrected by posteromedial release and that the recurrence of deformity can be reduced by splinting at night and often corrected by serial cast treatment.
Related Concept Videos
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Ankle Joint
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...
Diabetic Foot Ulcer

