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YM-47515, a novel isonitrile antibiotic from Micromonospora echinospora subsp. echinospora
1Chemistry Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan.
The Journal of Antibiotics
|May 21, 1998
Abstract:
During the course of our screening for new antibiotics, Micromonospora echinospora subsp. echinospora Y-03559J was found to produce a novel isonitrile compound, YM-47515 (1) along with a probable degradation product 2. The structure of 1 was assigned by spectroscopic analysis including 2D NMR and IR experiments. The relative stereochemistry of 1 was also proposed by comparison of spectral data with those of a closely related compound aerocyanidin (3). YM-47515 (1) showed promising antimicrobial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).