YM-47515, a novel isonitrile antibiotic from Micromonospora echinospora subsp. echinospora
Related Experiment Video
Updated: Oct 29, 2026

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
Published on: January 7, 2022
1Chemistry Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan.
Abstract:
During the course of our screening for new antibiotics, Micromonospora echinospora subsp. echinospora Y-03559J was found to produce a novel isonitrile compound, YM-47515 (1) along with a probable degradation product 2. The structure of 1 was assigned by spectroscopic analysis including 2D NMR and IR experiments. The relative stereochemistry of 1 was also proposed by comparison of spectral data with those of a closely related compound aerocyanidin (3). YM-47515 (1) showed promising antimicrobial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
More Related Videos
Related Concept Videos
Production of Antibiotics
Inhibitors of Bacterial DNA Synthesis
iChip
Inhibitors of Bacterial Protein Synthesis
Inhibitors of Gram-positive Cell Wall Synthesis
Antifungal Agents

