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Related Experiment Videos

[Coronary spasm--a clinically relevant problem?]

W Auch-Schwelk1

  • 1Medizinische Klinik IV (Kardiologie/Nephrologie), Klinikum der Johann-Wolfgang-Goethe-Universität Frankfurt. Auch-Schwelk@em.uni-frankfurt.de

Herz
|May 21, 1998
PubMed
Summary
This summary is machine-generated.

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Coronary spasms, or variant angina, involve reversible narrowing of coronary arteries. Diagnosis requires demonstrating hypercontractility, often provoked by ergonovine, with treatment focusing on calcium antagonists and nitrates.

Area of Science:

  • Cardiology
  • Vascular Physiology

Context:

  • Coronary spasms cause reversible coronary stenosis, limiting blood flow at rest.
  • Variant angina diagnosis relies on demonstrating coronary hypercontractility, either spontaneous or provoked.

Purpose:

  • To define coronary spasms and variant angina.
  • To outline diagnostic methods and clinical presentations.
  • To discuss risk factors, pathogenesis, and treatment.

Summary:

  • Ergonovine demonstrates high sensitivity and specificity for provoking coronary vasospasm.
  • Clinical manifestations include angina at rest, myocardial infarction, or syncope.
  • Pathogenesis remains unclear, though local inflammation and endothelial dysfunction are implicated.

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Impact:

  • Prevalence is underestimated due to infrequent provocation tests in Western countries.
  • Risk factors differ from atherosclerosis; smoking is a key factor for vasospasm.
  • Treatment involves calcium antagonists or nitrates; beta-blockers may worsen outcomes.