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Potentiated decrease of plasma folate levels caused by the coadministration of folic acid in rats treated with

K Inoue1, G Kudo, M Shimoda

  • 1Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Japan.

The Journal of Veterinary Medical Science
|May 21, 1998
PubMed
Summary

Methotrexate (MTX) decreases plasma 5-methyltetrahydrofolic acid (5-MF) levels, indicating altered folate status. Co-administration with folic acid (FA) potentiates this effect by inhibiting 5-MF renal reabsorption.

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