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[Patho-MR imaging study in the putaminal margin in multiple system atrophy]

M Konagaya1, M Sakai, Y Matsuoka

  • 1Department of Neurology, Suzuka National Hospital, Mie, Japan.

No to Shinkei = Brain and Nerve
|May 21, 1998
PubMed
Summary
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Slit hyperintensity in multiple system atrophy (MSA) on MRI is explained by widened tissue spaces in the putamen. This finding clarifies the nature of abnormal MRI signals in MSA patients.

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Multiple system atrophy (MSA) is a neurodegenerative disorder.
  • The slit hyperintensity in the putamen on T2-weighted MRI is a characteristic but poorly understood finding in MSA.

Observation:

  • A 63-year-old woman with a 9-year history of parkinsonism, ataxia, and dysautonomia underwent MRI.
  • MRI revealed pontocerebellar atrophy and slit hyperintensity in the putamen's margins.
  • Neuropathological examination showed severe degeneration and glial cytoplasmic inclusions.

Findings:

  • The putamen exhibited severe degeneration and rarefaction.
  • Widened intertissue spaces were observed at the putaminal margins.
  • This pathological finding directly correlates with the observed slit hyperintensity on MRI.

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Implications:

  • The study clarifies that slit hyperintensity in the putamen in MSA represents widened intertissue spaces.
  • This finding aids in understanding the pathophysiology of MSA.
  • It may improve the diagnostic accuracy of MRI in MSA.