A preliminary study of the physical stability of tablets prepared from powders stored under tropical conditions

A study has been made of the effects of storing powders under tropical conditions before compression on the physical stability of the tablets prepared from them, as measured by changes in tablet weight, volume and hardness. Significant changes in stability have been observed and these have been related to the different degrees of moisture uptake by the powders during storage. In addition, the initial powder storage conditions have been shown to be important when considering the best method of tablet manufacture with respect to tablet stability.