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Related Experiment Videos

Pattern and morphogenesis in skin

G P Moore1, N Jackson, K Isaacs

  • 1CSIRO, Division of Animal Production, Blacktown, NSW, 2148, Australia.

Journal of Theoretical Biology
|June 6, 1998
PubMed
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Follicle development involves distinct initiation sites and later branching, with final density not linked to initiation sites but correlated with wool fiber diameter. This suggests a committed cell population regulates both follicle number and fiber size.

Area of Science:

  • Developmental Biology
  • Dermatology
  • Animal Science

Background:

  • Existing models of hair and feather follicle development propose that initial morphogenetic factors dictate both follicle location and pattern.
  • These models often focus on early induction waves forming separate follicles, but later waves can produce compound follicles through branching.
  • Compound follicles significantly contribute to the total follicle population in some species.

Purpose of the Study:

  • To investigate the relationship between follicle initiation sites, final follicle density, and wool fiber characteristics in sheep.
  • To reconcile observations of later follicle development waves with existing models of follicle morphogenesis.
  • To propose a hypothesis explaining the developmental linkage between follicle density and fiber diameter.

Main Methods:

Related Experiment Videos

  • Analysis of follicle frequencies (single and branched) in sheep selection lines with varying follicle densities.
  • Comparison of primary/original secondary follicle populations (from initiation sites) with derived secondary populations (from branching).
  • Statistical correlation analysis between final follicle densities, initiation site densities, and wool fiber diameters.

Main Results:

  • Early follicles (primary, original secondary) originated from distinct 'initiation sites', while later follicles developed exclusively by branching.
  • Final follicle densities were not correlated with initiation site densities, indicating separate regulatory mechanisms.
  • A strong negative correlation was observed between final follicle density and wool fiber diameter, suggesting a developmental link.

Conclusions:

  • Follicle initiation site determination differs from mechanisms controlling final follicle number.
  • A population of committed cells, potentially the dermal papilla precursors, regulates both follicle initiation and fiber dimensions.
  • Follicle density is established earlier in development than mature follicle characteristics like fiber diameter.