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Interocular effect of actin depolymerization on spinule formation in teleost retina
1Departamento de Biotecnología, Facultad de Ciencias, Universidad de Alicante, Apdo. Correos 99, Alicante 03080, Spain.
Abstract:
Teleost retinas adapted to light show numerous spinules invaginated in the cone pedicles whereas darkness induces a reduction in the number of spinules. Horizontal cells show nematosomes whose size decreases as the number of spinules increases. We have investigated the involvement of actin filaments in spinule formation, by using cytochalasin D through intraocular injection into an eye. The ultrastructural analysis reveals that cytochalasin D impairs spinule formation and nematosome-size reduction in both treated and contralateral untreated retinas.
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