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Melanocortin-4 receptor mRNA expression in the developing autonomic and central nervous systems
1Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland 1, New Zealand. kmountjoy@auckland.ac.nz
Brain Research. Developmental Brain Research
|June 24, 1998
Abstract:
MC4-R mRNA expression was investigated in fetal rats (E14-E20) using in situ hybridisation. The autonomic nervous system showed the highest levels of MC4-R mRNA expression. In the spinal cord, dense signal was seen over the future intermediolateral cell column and dorsal horn. In the brain, MC4-R was expressed by E14 in diencephalon neuroepithelia, telencephalon, lamina terminalis and spinal trigeminal nucleus and was expressed by E19 throughout many regions of the brain.