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Evidence that GABA augmentation of norepinephrine release is mediated by interneurons
1Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Brain Research
|June 17, 1998
Abstract:
GABAA receptor activation augments stimulated release of 3H-norepinephrine (NE) in brain slices from female rats. This effect is not blocked by acetazolamide or MK-801, indicating that permeability of the GABAA chloride channel to bicarbonate ions and NMDA receptor activation do not mediate GABA-induced NE release. Furthermore, GABA augments 3H-NE release from slices, but not from isolated nerve terminals (synaptosomes), indicating that interneurons mediate GABA effects on 3H-NE release.