Related Experiment Videos
Expression of antimetastatic gene nm23-H1 in epithelial ovarian cancer
1Department of Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical University, China.
Objective:
To investigate the expression of nm23-H1 in epithelial ovarian cancer.
Methods:
A total of 55 specimens from patients with epithelial ovarian cancers, 15 patients with serous cancers, 7 with mucinous cancers, 17 with endometrioid cancers and 16 with adenocarcinomas, were examined for the expression of nm23-H1 by means of the immunohistochemical technique.
Results:
The total positive rate was 23.64% (13/55). The tissular nm23-H1 immunostaining had significantly higher expression in mucinous cancer (57.14%) than in other histologic types of epithelial ovarian cancer (P < 0.05). Compared to that in the primary tumor, nm23-H1 expression in the omental metastatic tumor in the same patient was reduced.
Conclusions:
The expression rate of nm23-H1 is higher in the primary tumors than in the metastatic tumors and is different in various histologic subtypes of epithelial ovarian cancer. The expression of nm23-H1 may participate in the inhibitory process of tumor invasion.