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Methacrylonitrile induced oxidative stress in rat liver
V Vasanthakumari1, S N Devaraj, H Devaraj
1Department of Homescience, Queen Mary's College, Madras.
Indian Journal of Biochemistry & Biophysics
|May 22, 1998
Abstract:
MeAN administration (40mg/kg body wt/day (i.e. 1/5 of LD50) resulted in increased levels of lipid peroxidation products, conjugated dienes and lipofuscin-like substances in rat liver. Significant decrease in GSH and a decreased activity of hepatic SOD, CAT and GPx were observed. There was also an increase in glutathione S-transferase and G6PD activities, decreased plasma ceruloplasmin and vitamin C implying oxidative stress caused by MeAN.