Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic instability and cancer

K Miyagawa1

  • 1Department of Molecular Pathology, Hiroshima University, Japan.

International Journal of Hematology
|May 22, 1998
PubMed
Summary
This summary is machine-generated.

Defects in DNA metabolism and genome integrity maintenance are linked to cancer. New research highlights four emerging areas of genetic instability, including DNA helicase mutations and recombinational repair, crucial for understanding tumor development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermoelectric signature of quantum critical phase in a doped spin-liquid candidate.

Nature communications·2023
Same author

Phase Diagram for Light-Induced Superconductivity in κ-(ET)_{2}-X.

Physical review letters·2021
Same author

Terahertz-field-induced polar charge order in electronic-type dielectrics.

Nature communications·2021
Same author

Electronic and spin structures of CaMn<sub>4</sub>O<sub></sub> clusters in the S<sub>0</sub> state of the oxygen evolving complex of photosystem II. Domain-based local pair natural orbital (DLPNO) coupled-cluster (CC) calculations using optimized geometries and natural orbitals (UNO) by hybrid density functional theory (HDFT) calculations.

Physical chemistry chemical physics : PCCP·2020
Same author

Topological charge transport by mobile dielectric-ferroelectric domain walls.

Science advances·2019
Same author

Strange metal from a frustration-driven charge order instability.

Nature materials·2019

Area of Science:

  • Genetics
  • Molecular Biology
  • Oncology

Background:

  • Defects in DNA metabolism (telomere maintenance, nucleotide excision repair, mismatch repair) are known contributors to tumor development.
  • Understanding the full spectrum of DNA metabolism defects is crucial for explaining the multiple mutations in cancer cells.

Purpose of the Study:

  • To explore four newly identified aspects of genetic instability.
  • To elucidate the connection between genome integrity defects and tumor development.

Main Methods:

  • Review of recent findings in DNA metabolism and genetic instability.
  • Analysis of mutations in DNA helicase genes, ataxia-telangiectasia gene, and genes related to recombinational repair (RAD51).
  • Investigation of conditional mutator phenotypes in mismatch-repair deficient cells.

Related Experiment Videos

Main Results:

  • Mutations in DNA helicase genes are linked to rare genetic instability syndromes and cancer predisposition.
  • Ataxia-telangiectasia gene mutations in sporadic leukemias suggest relevance of rare syndrome genes to sporadic tumor genesis.
  • Recombinational repair, particularly involving RAD51, is a significant area of interest due to links with breast cancer susceptibility.
  • A conditional mutator phenotype in mismatch-repair deficient cells indicates cancer can arise under specific conditions despite mutated stability genes.

Conclusions:

  • Emerging areas of DNA metabolism and genome integrity are critical for understanding cancer development.
  • Defects in DNA helicases, genes from rare syndromes, and recombinational repair pathways represent key factors in cancer predisposition and genesis.
  • Conditional instability mechanisms may explain tumor development even with mutated stability genes.