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[Enteroviral myocarditis and dilated cardiomyopathy]

R Kandolf1

  • 1Abteilung für Molekulare Pathologie, Universität Tübingen. kandolf@med.uni-tuebingen.de

Medizinische Klinik (Munich, Germany : 1983)
|May 22, 1998
PubMed
Summary

Enteroviruses, like coxsackieviruses, can persist in the heart, causing myocarditis and dilated cardiomyopathy. Molecular diagnosis helps distinguish viral persistence from immune-mediated heart disease.

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Area of Science:

  • Virology
  • Cardiology
  • Immunology

Context:

  • Enteroviruses, particularly coxsackieviruses (CVB), are detected in heart biopsies of patients with myocarditis.
  • These viral infections are also found in end-stage dilated cardiomyopathy, suggesting a causal link.

Purpose:

  • To investigate the role of enterovirus persistence in myocarditis and dilated cardiomyopathy.
  • To differentiate viral persistence from postviral immune-mediated cardiac disease using molecular diagnostics.

Summary:

  • In situ hybridization and PCR confirm enterovirus presence in myocardial biopsies, indicating potential heart persistence.
  • Molecular diagnosis of persistent enterovirus infection aids in differentiating viral from immune-mediated heart conditions.
  • Findings suggest therapeutic implications for managing myocarditis and dilated cardiomyopathy.

Impact:

  • Establishes enteroviruses as a potential cause of myocarditis and dilated cardiomyopathy.
  • Highlights the importance of molecular diagnostics for accurate etiologic diagnosis.
  • Informs therapeutic strategies, suggesting immunosuppression only after excluding viral persistence.

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