Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[GAD antibody in IDDM]

I Yokota1, K Shima

  • 1Department of Pediatrics, Tokushima University School of Medicine.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|May 22, 1998
PubMed
Summary
This summary is machine-generated.

Glutamic acid decarboxylase antibodies (GADAb) are key biomarkers for autoimmune diabetes. GADAb presence, particularly in relatives, can predict future beta-cell destruction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of SGLT2 inhibitors vs. DPP4 inhibitors for patients with metabolic dysfunction associated fatty liver disease and diabetes mellitus.

Journal of endocrinological investigation·2023
Same author

Surgical resection of primary tumor in the extremities improves survival for metastatic soft-tissue sarcoma patients: a population-based study of the SEER database.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2021
Same author

Low prevalence of maternal microchimerism in peripheral blood of Japanese children with type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same author

Estimation of glycaemic control in the past month using ratio of glycated albumin to HbA<sub>1c</sub>.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

Protein-altering variants of PTPN2 in childhood-onset Type 1A diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2017
Same author

FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children.

Diabetic medicine : a journal of the British Diabetic Association·2016

Area of Science:

  • Immunology
  • Endocrinology
  • Neuroscience

Context:

  • Glutamic acid decarboxylase (GAD) produces gamma-aminobutyric acid (GABA), a key neurotransmitter.
  • GAD65, a GAD isoform, is highly expressed in pancreatic beta-cells.
  • GAD acts as an autoantigen in human autoimmune diseases, notably insulin-dependent diabetes mellitus (IDDM).

Purpose:

  • To investigate the role of GAD autoantibodies (GADAb) in the development and prediction of autoimmune diabetes.
  • To analyze the diagnostic significance of GADAb in relation to other autoantibodies and clinical factors.

Summary:

  • GAD autoantibodies (GADAb) are crucial early indicators of autoimmune diabetes, often preceding other autoantibodies like IAA and ICA512/IA-2Ab.
  • GADAb are detected in 50-80% of IDDM patients at diagnosis, with titers influenced by age, sex, HLA type, and co-existing autoimmunity.

Related Experiment Videos

  • GADAb levels decline slower than other autoantibodies post-diagnosis, suggesting independent autoimmune pathways. GADAb presence in relatives predicts beta-cell destruction, especially with other islet autoantibodies.

    • Impact:

    • GADAb serve as vital predictive biomarkers for autoimmune diabetes onset and progression.
    • Understanding GADAb dynamics aids in early diagnosis and risk stratification for individuals with or at risk of diabetes.
    • The independent nature of GADAb development highlights potential therapeutic targets for autoimmune beta-cell destruction.