Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonrandom numerical chromosome abnormalities in basal cell carcinomas

Y Jin1, F Mertens, B Persson

  • 1Department of Genetics, Norwegian Radium Hospital, Oslo, Norway.

Cancer Genetics and Cytogenetics
|May 22, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased glomerular filtration rate in solderers exposed to cadmium.

Occupational and environmental medicine·1995
Same author

Scalp blood lactate: a new test strip method for monitoring fetal wellbeing in labour.

British journal of obstetrics and gynaecology·1995
Same author

Enzymuria in a population living near a cadmium battery plant.

Occupational and environmental medicine·1995
Same author

Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands.

Journal of immunological methods·1995
Same author

Cancer incidence and mortality of patients with suspected solvent-related disorders.

Scandinavian journal of work, environment & health·1995
Same author

Dynamic Octreotide scintigraphy in neuroendocrine tumours.

Acta radiologica (Stockholm, Sweden : 1987)·1995

Clonal chromosome abnormalities are common in basal cell carcinoma (BCC). These nonrandom genetic changes, particularly numerical aberrations in epithelial cells and rearrangements on chromosome 9q, may drive BCC development and warrant further investigation.

Area of Science:

  • Oncology
  • Cytogenetics
  • Dermatology

Background:

  • Basal cell carcinoma (BCC) is the most common human cancer.
  • The genetic underpinnings of BCC development are not fully understood.
  • Previous studies suggest chromosomal abnormalities play a role in BCC pathogenesis.

Purpose of the Study:

  • To investigate clonal chromosome abnormalities in short-term cultured basal cell carcinomas (BCC).
  • To identify nonrandom karyotypic changes and their potential role in BCC development.
  • To explore the contribution of both neoplastic and stromal cells to BCC pathogenesis.

Main Methods:

  • Short-term culture of 23 basal cell carcinoma (BCC) samples.
  • Karyotypic analysis to detect clonal chromosome abnormalities.

Related Experiment Videos

  • Distinguishing between abnormalities in epithelial and fibroblast-like cells.

    • Main Results:

    • Clonal chromosome abnormalities were detected in 22 of 23 BCC cultures.
    • Nonrandom karyotypic changes, including numerical aberrations (+18, +9, +20, +7, +5) and structural rearrangements of 9q, were observed.
    • Abnormalities in fibroblast-like cultures suggest stromal cell involvement.

    Conclusions:

    • Nonrandom clonal chromosome abnormalities are a hallmark of basal cell carcinoma (BCC).
    • Numerical changes in epithelial cells and rearrangements on chromosome 9q are potentially pathogenetically significant.
    • Stromal cell genetic alterations may also contribute to BCC development.