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Influence of smoking status on progression of endothelial dysfunction. TREND Investigators. Trial on Reversing

C J Pepine1, J D Schlaifer, G B Mancini

  • 1Department of Medicine, University of Florida, Gainesville, USA.

Clinical Cardiology
|May 22, 1998
PubMed

Insights

Cigarette smoking significantly impairs coronary endothelial function in patients with coronary artery disease. Smokers experienced a marked decline in endothelium-dependent vasomotor response over six months.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Clinical Research

Background:

  • Cigarette smoking is a primary risk factor for coronary artery disease (CAD).
  • Smoking exacerbates coronary morbidity and mortality in patients with atherosclerosis.
  • This study investigates smoking's impact on coronary endothelial function in specific CAD patient groups.

Purpose of the Study:

  • To evaluate the effect of smoking on coronary endothelial function in patients with established coronary artery disease.
  • To compare endothelial function between smokers and nonsmokers over a 6-month period.

Main Methods:

  • Subgroup analysis of 54 patients from a larger coronary endothelial function study.
  • Classification of patients as smokers or nonsmokers at baseline.
  • Coronary angiography performed at baseline and after 6-month follow-up.

Main Results:

  • Smokers showed a trend for greater vasoconstriction in response to acetylcholine at baseline compared to nonsmokers.
  • After 6 months, smokers exhibited a significantly greater vasoconstrictor response to acetylcholine.
  • No significant difference in nitroglycerin-induced vasodilation was observed between smokers and nonsmokers.

Conclusions:

  • A significant decline in endothelium-dependent vasomotor response occurs in current smokers over 6 months.
  • Smoking adversely affects endothelial function in patients with coronary artery disease.
Abstract

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