Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Septic shock

B Klosterhalfen1, R S Bhardwaj

  • 1Institute of Pathology, Technical University of Aachen, Germany.

General Pharmacology
|May 22, 1998
PubMed
Summary
This summary is machine-generated.

Septic shock remains a critical ICU complication. Research now explores intracellular pathways and heat shock response for novel therapeutic strategies, moving beyond blocking single inflammatory mediators.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Are late hernia mesh complications linked to Staphylococci biofilms?

Hernia : the journal of hernias and abdominal wall surgery·2022
Same author

Biofilms and effective porosity of hernia mesh: are they silent assassins?

Hernia : the journal of hernias and abdominal wall surgery·2019
Same author

Retrieval study at 623 human mesh explants made of polypropylene--impact of mesh class and indication for mesh removal on tissue reaction.

Journal of biomedical materials research. Part B, Applied biomaterials·2014
Same author

Characterisation of the cellular infiltrate in the foreign body granuloma of textile meshes with its impact on collagen deposition.

Hernia : the journal of hernias and abdominal wall surgery·2014
Same author

Retrieval study at 623 human mesh explants made of polypropylene - impact of mesh class and indication for mesh removal on tissue reaction.

Journal of biomedical materials research. Part B, Applied biomaterials·2013
Same author

Modified classification of surgical meshes for hernia repair based on the analyses of 1,000 explanted meshes.

Hernia : the journal of hernias and abdominal wall surgery·2012
Same journal

Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin.

General pharmacology·2002
Same journal

Reversal of hypercapnia induces endothelin-dependent constriction of basilar artery in rabbits with acute metabolic alkalosis.

General pharmacology·2002
Same journal

Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis.

General pharmacology·2002
Same journal

Contractile responses in spontaneously diabetic mice. II. Effect of cholestyramine on enhanced contractile response of aorta to norepinephrine in C57BL/KsJ (db/db) mice.

General pharmacology·2002
Same journal

Contractile responses in spontaneously diabetic mice. I. Involvement of superoxide anion in enhanced contractile response of aorta to norepinephrine in C57BL/KsJ(db/db) mice.

General pharmacology·2002
Same journal

Investigation of basal endothelial function in the obese Zucker rat in vitro.

General pharmacology·2002
See all related articles

Area of Science:

  • Critical care medicine
  • Immunology
  • Molecular biology

Background:

  • Septic shock is a significant complication in intensive care units (ICUs).
  • Previous trials targeting tumor necrosis factor, interleukin-1, and endotoxin yielded unsatisfactory results.
  • Current research focuses on cytokine pathways, including anti-inflammatory cytokines like interleukin 10.

Purpose of the Study:

  • To review recent advancements in understanding septic shock pathophysiology.
  • To highlight novel research approaches, such as the heat shock response, in septic shock treatment.

Main Methods:

  • Review of current literature on septic shock.
  • Analysis of intracellular signaling pathways in inflammation.
  • Examination of the role of heat shock proteins in septic shock.

Related Experiment Videos

Main Results:

  • Growing knowledge of intracellular activation and deactivation pathways offers opportunities for early and specific inflammatory response modulation.
  • The heat shock response represents a promising new avenue for septic shock research.

Conclusions:

  • Understanding septic shock pathophysiology is evolving.
  • Targeting intracellular pathways and heat shock response may provide more effective therapeutic strategies for septic shock.