Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelin interactions with brain dopamine systems

K M Webber1, C A Wallace, A I Smith

  • 1Baker Medical Research Institute, Prahran, Victoria, Australia.

Journal of Cardiovascular Pharmacology
|May 22, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Verification of single-photon path entanglement using a nitrogen vacancy center.

Applied optics·2025
Same author

Impact of hypoxia-ischemia and dopamine treatment on dopamine receptor binding density in the preterm fetal sheep brain.

Journal of applied physiology (Bethesda, Md. : 1985)·2020
Same author

Feeding synthetic zeolite to transition dairy cows alters neutrophil gene expression.

Journal of dairy science·2019
Same author

Effect of adolescent androgen manipulation on psychosis-like behaviour in adulthood in BDNF heterozygous and control mice.

Hormones and behavior·2019
Same author

The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair.

Translational psychiatry·2017
Same author

Differential effects of antipsychotic drugs on serotonin-1A receptor-mediated disruption of prepulse inhibition.

Acta neuropsychiatrica·2016
Same journal

Integration of Mendelian Randomization and FAERS Database Analysis Reveals the Association Between Ergotamine and Aortic and Mitral Valve Diseases.

Journal of cardiovascular pharmacology·2026
Same journal

A Comprehensive Review of PCSK9 Inhibitor Therapy.

Journal of cardiovascular pharmacology·2026
Same journal

SGLT2 Inhibitors and Progression of Chronic Kidney Disease in Patients with Elevated Lipoprotein(a): A Real-World Cohort Study.

Journal of cardiovascular pharmacology·2026
Same journal

Aspirin in primary prevention: a case for selective use.

Journal of cardiovascular pharmacology·2026
Same journal

GLP-1 Gene Therapy Trial for Obesity and Type 2 Diabetes: Towards a New Paradigm for Chronic Disease Treatment.

Journal of cardiovascular pharmacology·2026
Same journal

Expert Opinion: Restrictions, Precautions, or Normalcy? Defining Everyday Risk in Patients Treated With IL-1 Blockers for Recurrent Pericarditis.

Journal of cardiovascular pharmacology·2026
See all related articles

Endothelin (ET) levels in rat brain regions were quantified. Dopamine depletion did not alter ET levels, and ET levels were lower in specific brain areas of spontaneously hypertensive rats.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Pharmacology

Background:

  • Endothelin (ET) is a peptide with known cardiovascular effects.
  • Dopaminergic systems are crucial for motor control and reward.
  • The interaction between ET and dopaminergic systems in the brain is not fully understood.

Purpose of the Study:

  • To investigate the distribution and regulation of endothelin (ET) in rat brain.
  • To examine the relationship between ET and dopaminergic systems.
  • To compare ET levels in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats.

Main Methods:

  • High-Performance Liquid Chromatography (HPLC) for peptide separation.
  • Radioimmunoassay (RIA) for quantifying immunoreactive ET.

Related Experiment Videos

  • Dopamine depletion in rat striatum.
  • Comparison of ET levels between SHR and WKY rats.

    • Main Results:

    • Striatum showed the highest levels of ET-1; pituitary had the highest levels of ET-3.
    • Dopamine depletion in the striatum did not affect immunoreactive ET levels.
    • ET levels were lower in the cerebellum and medulla of SHR compared to WKY rats, but not different in other brain areas.

    Conclusions:

    • Endothelin is present in high concentrations in the rat striatum.
    • Striatal ET levels are independent of dopamine depletion.
    • Hypertension in SHR is associated with altered ET levels in specific brain regions, but not universally across the brain.