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[Arterial dysfunction as a possible mechanism of cardiac injury in type II diabetic patients. A
B B Matsubara1, K Okoshi, M P Okoshi
1Depto de Clínica Médica, Faculdade de Medicina de Botucatu-UNESP.
Insights
Type II diabetes is linked to increased arterial stiffness and left ventricular mass index, potentially impacting cardiac morphology. These findings highlight the cardiovascular risks associated with diabetes.
Area of Science:
- Cardiology
- Endocrinology
- Vascular Medicine
Background:
- Type II diabetes mellitus is a growing global health concern.
- Diabetic patients often exhibit cardiovascular complications.
- Understanding the impact of diabetes on cardiac structure and vascular health is crucial.
Purpose of the Study:
- To assess left ventricular structure and function in type II diabetic patients.
- To evaluate arterial stiffness in individuals with type II diabetes.
- To compare these parameters with a healthy control group.
Main Methods:
- Doppler-echocardiography was used to examine cardiac structure and function.
- Non-invasive arterial blood pressure monitoring assessed arterial stiffness.
- A cohort of 13 type II diabetic patients was compared to 12 age- and sex-matched controls.
Main Results:
- Diabetic patients showed significantly increased left ventricular mass index (p < 0.001).
- Increased arterial stiffness was observed in diabetic patients compared to controls (p < 0.05).
- No significant differences were found in diastolic blood pressure, cardiac chamber dimensions, or ventricular systolic/diastolic function indexes.
Conclusions:
- Diabetes mellitus is associated with elevated systemic arterial stiffness.
- Increased arterial stiffness may contribute to adverse left ventricular remodeling in diabetes.
- These findings underscore the importance of managing vascular health in type II diabetes.
Purpose:
To evaluate the left ventricular structure and function and the arterial stiffness in type II diabetic patients.
Methods:
Thirteen diabetic patients, men and women (age 55 +/- 8 years) were included in the study. None of the patients had any other clinical disorders. Doppler-echocardiography and non-invasive monitoring of arterial blood pressure were performed. All the results were compared to an age and sex matched control group (n = 12).
Results:
There were no differences between the groups for diastolic blood pressure, dimensions of cardiac chambers and ventricular systolic and diastolic function indexes. Diabetic patients had increased left ventricular mass index (101 +/- 10 vs 80 +/- 14 g/m2; p < 0.001) and increased arterial stiffness (0.86 +/- 0.26 vs 0.69 +/- 0.19 mmHg/mL; p < 0.05), when compared to control group.
Conclusion:
Diabetes mellitus is associated to increased systemic arterial stiffness and this may contribute to the adverse effects of diabetes on left ventricular morphology.