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Neuromodulation and Mitochondrial Transport: Live Imaging in Hippocampal Neurons over Long Durations
Published on: June 17, 2011
Lead as an inductor of changes in the citrate transport to rat brain synaptic mitochondria
J Waśkiewicz1, A Lenkiewicz, U Rafałowska
1Department of Neurochemistry, Polish Academy of Sciences, Warszawa.
Abstract:
The aim of the experiments presented here was to discern whether prolonged consumption of leaden water, that imitates environmental exposure, affects citrate transport to synaptic mitochondria. Our results indicate that during chronic lead intoxication both the velocity and the affinity of citrate transport to synaptic mitochondria decreased affecting the operation of Krebs cycle and consequently energetic processes in these mitochondria.
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