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Related Experiment Videos

[Tri-test: clinical considerations on 1784 cases]

D Caserta1, M Baldi, G Carta

  • 1Dipartimento di Discipline Chirurgiche, Università degli Studi, L'Aquila.

Minerva Ginecologica
|May 22, 1998
PubMed
Summary
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The triple screen serum test shows 66% sensitivity for detecting Down syndrome in expectant mothers over 35. Adjusting the cutoff may improve accuracy by reducing false positives.

Area of Science:

  • Obstetrics and Gynecology
  • Medical Diagnostics
  • Genetics

Context:

  • The triple screen serum test is a noninvasive method for screening chromosomal abnormalities.
  • Expectant mothers over 35 are typically candidates for invasive screening for trisomy 21.
  • This study evaluated the triple screen test in mothers aged 35 and older.

Purpose:

  • To assess the efficacy of the triple screen serum test in identifying trisomy 21 in expectant mothers over 35.
  • To determine the sensitivity and false positive rates of the triple screen test in this demographic.

Summary:

  • 1784 triple screen tests were conducted between 15-18 weeks of gestation.
  • The test yielded a 13.60% positive rate, with false positives at 12.9% (age < 35) and 28% (age > 35).

Related Experiment Videos

  • Sensitivity was 66%, with two cases of Down syndrome confirmed via amniocentesis among positive results. One case of Down syndrome occurred in the negative group.

    • Impact:

    • The study highlights a 66% sensitivity for the triple screen test in mothers over 35.
    • High false positive rates necessitate adjustments to screening protocols.
    • A revised cutoff value (1:300) is proposed to enhance the test's predictive value.