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Related Experiment Videos

Two olfactory marker proteins in Xenopus laevis

P Rössler1, M Mezler, H Breer

  • 1University Stuttgart-Hohenheim, Institute of Physiology, Stuttgart, Germany.

The Journal of Comparative Neurology
|May 22, 1998
PubMed
Summary

Two olfactory marker protein (OMP) genes in Xenopus laevis show distinct regional expression in the nasal epithelium. This suggests specialized roles for OMP subtypes in detecting airborne versus water-borne odorants.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Olfactory receptor neurons (ORNs) in mammals express the conserved olfactory marker protein (OMP).
  • OMP is crucial for mature ORN function and is encoded by single-copy genes.

Purpose of the Study:

  • To identify and characterize OMP homologs in Xenopus laevis.
  • To investigate the expression patterns and potential functional significance of these OMP subtypes in the amphibian olfactory system.

Main Methods:

  • Sequence comparison of Xenopus OMP genes (XOMP1, XOMP2) with mammalian OMPs.
  • Analysis of regional expression of XOMP1 and XOMP2 transcripts in the Xenopus olfactory nasal epithelium.

Main Results:

  • Two homologous OMP genes were identified in Xenopus laevis, sharing ~50% sequence identity with mammalian OMPs.

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  • Sequence analysis revealed conserved internal domains but variable N- and C-termini between amphibian and mammalian OMPs.
  • XOMP1 transcripts were predominantly found in the lateral nasal epithelium, while XOMP2 transcripts were more abundant in the medial region.

    • Conclusions:

    • The identified Xenopus OMP subtypes (XOMP1 and XOMP2) exhibit distinct spatial expression patterns within the olfactory epithelium.
    • These regional expression patterns suggest specialized functions, potentially correlating with the detection of water-borne (lateral) and air-borne (medial) odorants, respectively.