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[A study on the expression of three cytokine-receptors and airway hyperreactivity in asthmatics after specific
Objective:
In order to study the role of T and B lymphocytes activation in the pathogenesis of asthma.
Method:
Pulmonary function tests were performed and percentages of three cytokine receptors and the levels of sIL-2R, sIgE and TIgE were measured in 31 allergic asthmatics and 12 healthy subjects before and after specific provocation.
Results:
It was found that the serum levels of sIL-2R (t = 5,719, 5,647 P < 0.01), TIgE were measured in 31 allergic asthmatics and 12 healthy (t = 6,306, 7,218 P < 0.01) and percentages of CD+23 (chi(2) -23.43, 18.56 P < 0.01) or CD+(25) (chi(2) = 27.59, 15. 28) cells were significantly higher in asthmatics after challenge than those in controls or in asthmatics before challenge as well; There were significantly negative correlations between sIL-2R and FEV1 or sGaw (r = -0.573, -0.426 P < 0.01), whereas positive correlations between sIL-2R and Raw or percent of IL-2R/CD+(25) cells (r = 0.417, 0.532 P < 0.01); TIgE and percent of Fc epsilon R II/CD+(23) cells (r = 0.603 P < 0.01), respectively.
Conclusion:
These findings suggest that T cell activation, increased serum levels of sIL-2R and increased expression of CD+(25) or CD+(23) on cells, may lead to enhanced AHR in allergic asthmatics.