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[Differentiation of cytology of BALF between BOOP and UIP]
1Department of Respiratory Disease, First Affiliated Hospital, Guangxi Medical University, Nanning.
Objective:
BOOP is a disease entity proposed by Epler in 1985, and UIP is considered an important disease to be differentiated from BOOP. The aim of this study was to identify characteristic features in BALF samples of patients with BOOP and UIP.
Methods:
Differential cell count and T-cell subpopulation of the BALF obtained from 7 patients with BOOP and 7 patients with UIP, both histologically verified, were determined.
Results:
In BOOP patients the ratio of lymphocytes and the CD8+ cell in BALF were significantly higher and CD4+/cd8+ ratio was significantly lower than those of the UIP patients (P < 0.01). In UIP patients the ratio of neutrophils in BALF was significantly higher than that of the BOOP patients (P < 0.05).
Conclusions:
Cytological examination of BALF is effective in differentiating BOOP from UIP and it can provide useful information about both different pathogenetic processes of the two entities.