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HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium
T Mrowiec1, C Melchar, A Górski
1Department of Immunology, Transplantation Institute, University Medical School, Warsaw, Poland.
Recent data point to the immunoregulatory role of extracellular matrix (ECM) proteins in the process of T cell activation. We studied the effects of HIV proteins on those interactions as well as on endothelial adhesion molecule expression. Gp 120 and gp 41 inhibited CD3-triggered T cell co-stimulation by the ECM proteins, while Nef was stimulatory. T cell adhesion to the ECM proteins was affected in a similar fashion. Furthermore, tat induced E-selectin (but not VCAM-1 and ICAM-1) endothelial expression. Those findings may be relevant for the understanding of immunopathology of AIDS.
Recent data point to the immunoregulatory role of extracellular matrix (ECM) proteins in the process of T cell activation. We studied the effects of HIV proteins on those interactions as well as on endothelial adhesion molecule expression. Gp 120 and gp 41 inhibited CD3-triggered T cell co-stimulation by the ECM proteins, while Nef was stimulatory. T cell adhesion to the ECM proteins was affected in a similar fashion. Furthermore, tat induced E-selectin (but not VCAM-1 and ICAM-1) endothelial expression. Those findings may be relevant for the understanding of immunopathology of AIDS.